We suggest running the buffer at the very end of your pedalboard for a couple of reasons. Number one, this puts it closest to the amp preventing you from losing more signal after the buffer due to cable length. Second, buffers tend to not play nice if placed in front of some pedals, especially fuzz pedals, so placing them after allows the fuzz to get hit with the original signal and go through the buffer retaining it’s original sound. However, as with any pedal, experimentation is the best way to figure out what works best for you. At the end is just our personal preference.
All buffers are not made equal either, you’ll find some of the internal buffers in effects pedals are not doing their job quite as well as a dedicated buffer like ours can. At trade shows we often showcase this by allowing someone to play our demo board through an amp with a popular buffered pedal at the end of the board. We then pull that pedal off and replace it with our buffer and let the person play through the board again and this typically converts people to using a dedicated buffer like ours. The difference is very noticeable!